Emerging Functions of Extracellular Pyridine Nucleotides

Extracellular pyridine nucleotides as immune elicitors in arabidopsis

The pyridine nucleotides nicotinamide adenine dinucleotide (NAD) and NAD phosphate (NADP) are coenzymes that function in both metabolic reactions and intracellular signaling. Emerging evidence from animal research indicates that NAD(P) also acts in the extracellular space (ECS). We have shown in the model plant Arabidopsis that (1) exogenous NAD(P) induces immune responses, (2) pathogen infecti...

The stability of pyridine nucleotides.

Diphosphopyridine nucleotide and triphosphopyridine nucleotide when used in appropriate enzyme systems become exceedingly useful reagents for the measurement of almost any biochemical substance. A companion paper describes procedures for measuring each of the pyridine nucleotides, whether in the oxidized or reduced form, at concentrations as low as 1O-g M and in amounts as small as lo-l5 moles ...

Extracellular nucleotides regulate cellular functions of podocytes in culture.

Extracellular nucleotides are assumed to be important regulators of glomerular functions. This study characterizes purinergic receptors in podocytes. The effects of purinergic agonists on electrophysiological properties and the intracellular free Ca(2+) concentration of differentiated podocytes were examined with the patch-clamp and fura 2 fluorescence techniques. mRNA expression of purinergic ...

Pyridine nucleotides in erythrocyte metabolism.

Streptozotocin: depression of mouse liver pyridine nucleotides.

phenomenon readily prevented by nicotinamide pretreatment (21). This communication deals with the changes in liver NAD and reduced nicotinamide adenine dinucleotide (NADH) con centrations over a 48-hour period following the single intra venous administration of Streptozotocin. These effects are cor related with the measurement of drug concentration in serum and the acid-soluble fraction of live...